1. Pharmacological effects and synergistic mechanism
Diosmin
Mechanism of action: As a semi-synthetic derivative of hesperidin, Diosmin acts mainly through the following ways:
Enhancing venous tone: prolonging the norepinephrine-induced venous contraction time and improving venous elasticity.
Improving microcirculation: Reducing blood viscosity, accelerating blood flow and reducing capillary permeability.
Promote lymphatic return: accelerate tissue fluid return, reduce edema.
Anti-inflammatory and antioxidant: inhibit the release of inflammatory mediators (e.g. histamine, prostaglandins), scavenging free radicals.
Hesperidin (Hesperidin)
A natural flavonoid, pharmacological effects include:
Antioxidant: scavenging free radicals and protecting the vascular endothelium.
Anti-inflammatory: inhibit inflammatory factors such as TNF-α and IL-6.
Regulating blood lipids: lowering LDL cholesterol and elevating HDL cholesterol.
Improve microcirculation: enhance capillary toughness, prevent varicose veins.
2. Synergistic effect
Enhance venous function: Diosmin directly enhances venous tone, Hesperidin stabilizes the vessel wall through antioxidant.
Reduce inflammation and edema: both inhibit the release of inflammatory mediators and synergistically improve lymphatic circulation.
Vascular protection: Hesperidin’s antioxidant effect can enhance the vascular protection effect of Diosmin.
Indications and clinical applications
Core indications
Chronic venous insufficiency: improve the symptoms of lower limb heaviness, pain and edema.
Hemorrhoids: relief of symptoms during acute attacks, long-term use to reduce recurrence.
Varicose veins: relieve leg soreness, pain and earthworm-like bulging of blood vessels.
Microcirculation disorders: such as diabetic microangiopathy, premenstrual syndrome.
Other uses
Lymphedema (e.g., postoperative upper extremity edema after breast cancer).
Prevention of thromboembolism (pre- and post-operative adjunct).
Adjunctive lowering of blood pressure (vasodilatory effect of hesperidin).