1. Pharmacological effects and synergistic mechanism<\/p>\n\n\n\n
Diosmin<\/p>\n\n\n\n
Mechanism of action: As a semi-synthetic derivative of hesperidin, Diosmin acts mainly through the following ways:<\/p>\n\n\n\n
Enhancing venous tone: prolonging the norepinephrine-induced venous contraction time and improving venous elasticity.<\/p>\n\n\n\n
Improving microcirculation: Reducing blood viscosity, accelerating blood flow and reducing capillary permeability.<\/p>\n\n\n\n
Promote lymphatic return: accelerate tissue fluid return, reduce edema.<\/p>\n\n\n\n
Anti-inflammatory and antioxidant: inhibit the release of inflammatory mediators (e.g. histamine, prostaglandins), scavenging free radicals.<\/p>\n\n\n\n
Hesperidin (Hesperidin)<\/p>\n\n\n\n
A natural flavonoid, pharmacological effects include:<\/p>\n\n\n\n
Antioxidant: scavenging free radicals and protecting the vascular endothelium.<\/p>\n\n\n\n
Anti-inflammatory: inhibit inflammatory factors such as TNF-\u03b1 and IL-6.<\/p>\n\n\n\n
Regulating blood lipids: lowering LDL cholesterol and elevating HDL cholesterol.<\/p>\n\n\n\n
Improve microcirculation: enhance capillary toughness, prevent varicose veins.<\/p>\n\n\n\n
2. Synergistic effect<\/p>\n\n\n\n
Enhance venous function: Diosmin directly enhances venous tone, Hesperidin stabilizes the vessel wall through antioxidant.<\/p>\n\n\n\n
Reduce inflammation and edema: both inhibit the release of inflammatory mediators and synergistically improve lymphatic circulation.<\/p>\n\n\n\n
Vascular protection: Hesperidin’s antioxidant effect can enhance the vascular protection effect of Diosmin.<\/p>\n\n\n\n
Indications and clinical applications<\/p>\n\n\n\n
Core indications<\/p>\n\n\n\n
Chronic venous insufficiency: improve the symptoms of lower limb heaviness, pain and edema.<\/p>\n\n\n\n
Hemorrhoids: relief of symptoms during acute attacks, long-term use to reduce recurrence.<\/p>\n\n\n\n
Varicose veins: relieve leg soreness, pain and earthworm-like bulging of blood vessels.<\/p>\n\n\n\n
Microcirculation disorders: such as diabetic microangiopathy, premenstrual syndrome.<\/p>\n\n\n\n
Other uses<\/p>\n\n\n\n
Lymphedema (e.g., postoperative upper extremity edema after breast cancer).<\/p>\n\n\n\n
Prevention of thromboembolism (pre- and post-operative adjunct).<\/p>\n\n\n\n
Adjunctive lowering of blood pressure (vasodilatory effect of hesperidin).<\/p>\n","protected":false},"excerpt":{"rendered":"
1. Pharmacological effects and synergistic mechanism Diosmin Mechanism of action: As a semi-synthetic derivative of hesperidin, Diosmin acts mainly through the following ways: Enhancing venous tone: prolonging the norepinephrine-induced venous contraction time and improving venous elasticity. Improving microcirculation: Reducing blood viscosity, accelerating blood flow and reducing capillary permeability. Promote lymphatic return: accelerate tissue fluid return, […]<\/p>\n","protected":false},"author":3,"featured_media":1850,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1849","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news"],"_links":{"self":[{"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/posts\/1849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1849"}],"version-history":[{"count":1,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/posts\/1849\/revisions"}],"predecessor-version":[{"id":1851,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/posts\/1849\/revisions\/1851"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/media\/1850"}],"wp:attachment":[{"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}