Hesperidin (orange peel glycoside) is a flavonoid found in citrus fruits that has several health benefits and a wide range of applications. The following is a detailed summary of the benefits of hesperidin:<\/p>\n\n\n\n
1. Antioxidant and anti-inflammatory effects<\/p>\n\n\n\n
Antioxidant<\/p>\n\n\n\n
Hesperidin is a potent free radical scavenger, can neutralize excess reactive oxygen species in the body (such as superoxide anion, hydroxyl radicals, etc.), to reduce oxidative stress damage to cells, DNA and proteins.<\/p>\n\n\n\n
Mechanism: Activate the key transcription factor Nrf2. an intracellular antioxidant, to promote the expression of heme oxygenase-1 (HO-1) and enhance the cell’s own antioxidant defense.<\/p>\n\n\n\n
Anti-inflammatory<\/p>\n\n\n\n
By inhibiting the production and release of inflammatory mediators (e.g. TNF-\u03b1, IL-6), it reduces chronic inflammatory responses and helps to alleviate inflammation-related diseases.<\/p>\n\n\n\n
2. Cardiovascular protection<\/p>\n\n\n\n
Lowering blood pressure<\/p>\n\n\n\n
Studies have shown that a single oral dose of hesperidin (10-50mg\/kg) can significantly reduce systolic blood pressure in spontaneously hypertensive rats, and the effect lasts for 9-12 hours.<\/p>\n\n\n\n
Mechanism: Enhance endothelium-dependent vasodilatory function, increase the bioavailability of nitric oxide (NO).<\/p>\n\n\n\n
Regulation of blood lipids<\/p>\n\n\n\n
Reduce the level of low-density lipoprotein cholesterol (LDL-C), increase the level of high-density lipoprotein cholesterol (HDL-C), prevent atherosclerosis.<\/p>\n\n\n\n
Improve vascular endothelial function<\/p>\n\n\n\n
Protecting vascular endothelial cells, maintaining vascular integrity, increasing the tension and elasticity of capillary walls.<\/p>\n\n\n\n
3. Other Health Benefits<\/p>\n\n\n\n
Anti-aging and neuroprotection<\/p>\n\n\n\n
Muscle health: Studies have confirmed that hesperidin improves muscle degeneration in aged mice and reduces muscle loss by regulating the immune balance (inhibiting pro-inflammatory M1 macrophages and promoting tissue-repairing M2 macrophages).<\/p>\n\n\n\n
Neuroprotection: Protection of nerve cells from oxidative damage may have a positive effect on the prevention of neurodegenerative diseases.<\/p>\n\n\n\n
Anti-tumor potential<\/p>\n\n\n\n
Some studies suggest that hesperidin may inhibit the proliferation of cancer cells, especially in colon and breast cancer, showing potential effects by mechanisms including inducing apoptosis or blocking DNA synthesis.<\/p>\n\n\n\n
Promote intestinal health<\/p>\n\n\n\n
Enhance the intestinal barrier function, reduce the harmful substances through the intestinal wall into the blood circulation, assist in relieving gastric ulcers and other digestive disorders.<\/p>\n\n\n\n
Improve microcirculation<\/p>\n\n\n\n
Increase the toughness of capillaries and prevent microcirculation disorders such as varicose veins and hemorrhoids.<\/p>\n\n\n\n
Application Fields<\/p>\n\n\n\n
Medicine and health care products<\/p>\n\n\n\n
Used in the prevention and treatment of cardiovascular diseases (e.g. hypertension, arteriosclerosis).<\/p>\n\n\n\n
Regulate blood sugar, blood lipid, assist in improving metabolic syndrome.<\/p>\n\n\n\n
Used as antioxidant in health care products to delay aging.<\/p>\n\n\n\n
Food Industry<\/p>\n\n\n\n
Natural additives: used as coloring agent (giving yellow color to food) and bittering agent for beverages, candies, condiments, etc.<\/p>\n\n\n\n
Functional fortification: Enhance the effect of vitamin C and promote its absorption and utilization in the body.<\/p>\n\n\n\n
Daily chemical field<\/p>\n\n\n\n
Skin whitening: inhibit tyrosinase activity, reduce melanin production, used in spot removal and whitening products.<\/p>\n\n\n\n
Antibacterial and antiviral: Large doses of methyl hesperidin can inhibit the reproduction of influenza virus and enhance immunity.<\/p>\n","protected":false},"excerpt":{"rendered":"
Hesperidin (orange peel glycoside) is a flavonoid found in citrus fruits that has several health benefits and a wide range of applications. The following is a detailed summary of the benefits of hesperidin: 1. Antioxidant and anti-inflammatory effects Antioxidant Hesperidin is a potent free radical scavenger, can neutralize excess reactive oxygen species in the body […]<\/p>\n","protected":false},"author":3,"featured_media":1841,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1840","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-news"],"_links":{"self":[{"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/posts\/1840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1840"}],"version-history":[{"count":2,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/posts\/1840\/revisions"}],"predecessor-version":[{"id":1843,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/posts\/1840\/revisions\/1843"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=\/wp\/v2\/media\/1841"}],"wp:attachment":[{"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/diosmin-hesperidin.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}